Normal Pubertal Physiology in Females

J.E. Dietrich (ed.), Female Puberty: A Comprehensive Guide for Clinicians, DOI 10.1007/978-1-4939-0912-4_2, © Springer Science+Business Media New York 2014 Abstract The development of a female child into an adult woman is a complex process. Puberty, and the hormones that fuel the physical and psychological changes which are its hallmarks, is generally viewed as a rough and often unpredictable storm that must be weathered by the surrounding adults. The more we learn, however, about the intricate interplay between the endocrine regulators and the endorgan responses to this hormonal symphony, puberty seems less like chaos, and more of an incredible metamorphosis that leads to reproductive capacity and psychosocial maturation. Physically, female puberty is marked by accelerated growth and the development of secondary sexual characteristics. Secondary sexual characteristics are those that distinguish two different sexes in a species, but are not directly part of the reproductive system. Analogies from the animal kingdom include manes in male lions and the elaborate tails of male peacocks. The visible/external sequence of events is generally: breast budding (thelarche), onset of pubic hair (pubarche), maximal growth velocity, menarche, development of axillary hair, attainment of the adult breast type, adult pubic hair pattern. Underlying these external developments is the endocrine axis orchestrating the increase in gonadal steroid production (gonadarche), the increase in adrenal androgen production (adrenarche) and the associated changes in the reproductive tract that allow fertility. Meanwhile, the brain is rapidly adapting to the new hormonal milieu. The extent of variation in this scenario is enormous. On average, the process from accelerated growth and breast budding to menarche is approximately 4.5 years with a range from 1.5 to 6 years. There are differences in timing and expression of maturation based on ethnicity, geography, and genetics. Being familiar with the spectrum that encompasses normal development is Chapter 2 Normal Pubertal Physiology in Females